The word "Semplici" refers to the raw ingredients, "simples", used by medieval apothecaries in preparing medicine- thus the Giardino dei Semplici was where medicinal herbs were grown and studied. It was set up in 1545 by Niccolò Tribolo for Cosimo I in the area between Via Micheli, Via Giorgio la Pira and Via Gino Capponi. The garden retains its original layout but now the collection includes tropical plants as well as flora native to Tuscany.
Around the garden are small specialist museums: a geology collection includes fossils; the mineralogy section shows the geological structure of Elba, whose ores attracted bronze traders in the 10th century BC. The botanical museum has specimens of rare plants.